MMADHC and MMACHC

Number of citations of the paper that reports this interaction (PubMedID 21071249)
12

Data Source:
BioGRID (pull down, two hybrid)

		MMADHC	MMACHC
Description		metabolism of cobalamin associated D	metabolism of cobalamin associated C
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Oxidoreductase Activity Transferase Activity Cobalamin Binding Demethylase Activity Cyanocobalamin Reductase (cyanide-eliminating) Activity Protein Homodimerization Activity Glutathione Binding FAD Binding
	Biological Process	Cobalamin Metabolic Process	Glutathione Metabolic Process Cobalamin Metabolic Process Demethylation
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD	Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Drugs			Cyanocobalamin Hydroxocobalamin
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Liver enzyme levels (alanine transaminase) ( 24124411) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095)	Blood protein levels ( 28240269) Homocysteine levels ( 23824729)
Interacting Genes		7 interacting genes: CINP CREB5 EPC2 MMACHC POU4F2 PRNP TBC1D7	2 interacting genes: KDM4A MMADHC
Entrez ID		27249	25974
HPRD ID		10781	18585
Ensembl ID		ENSG00000168288	ENSG00000132763
Uniprot IDs		Q9H3L0	A0A0C4DGU2 Q9Y4U1
PDB IDs		5CUZ 5CV0 6X8Z	3SBY 3SBZ 3SC0 3SOM 5UOS
Enriched GO Terms of Interacting Partners?
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