TUBGCP4 and RNF146

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		TUBGCP4	RNF146
Description		tubulin gamma complex associated protein 4	ring finger protein 146
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GO Annotations	Cellular Component	Spindle Pole Equatorial Microtubule Organizing Center Gamma-tubulin Complex Gamma-tubulin Large Complex Centrosome Cytosol Microtubule Microtubule Cytoskeleton Membrane Recycling Endosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Gamma-tubulin Binding Microtubule Minus-end Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Poly-ADP-D-ribose Binding
	Biological Process	Mitotic Cell Cycle Microtubule Nucleation Cytoplasmic Microtubule Organization Spindle Assembly Meiotic Cell Cycle Protein-containing Complex Assembly	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes	TCF dependent signaling in response to WNT Degradation of AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs
Diseases
GWAS		Glycine levels ( 30837465) HDL cholesterol ( 30275531) Liver enzyme levels (alkaline phosphatase) ( 33972514) Triglycerides ( 30275531)	Breast cancer ( 18326623) Diverticular disease ( 30177863) Food addiction ( 27106561) Intracranial volume ( 22504418) LDL cholesterol levels in HIV infection ( 33109212) Subcortical brain region volumes ( 25607358) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		33 interacting genes: ADAMTSL4 ADD3 AP2B1 CBY2 CCDC85B CHIC2 DGCR6 EFHC2 FBF1 FDXACB1 GFAP GLYCTK GOLGA2 KCTD17 KRT15 KRT18 KRT4 KRT6B LZTR1 MAD1L1 NUDT3 PAK5 PHKA1 RNF146 RPRD1B SDSL STN1 TRIM27 TRIM55 TRIM63 TUBG1 USHBP1 VIM	11 interacting genes: KASH5 NDUFAF3 PFN2 TGFBR1 TRAF2 TUBGCP4 UBE2D2 UBE2G2 UBE2H XRCC1 XRCC6
Entrez ID		27229	81847
HPRD ID		10616	11511
Ensembl ID		ENSG00000137822	ENSG00000118518
Uniprot IDs		Q9UGJ1	Q9NTX7
PDB IDs		3RIP 6V69 6V6S 7AS4	2D8T 3V3L 6CF6
Enriched GO Terms of Interacting Partners?
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