GLA and PDE6B

		GLA	PDE6B
Description		galactosidase alpha	phosphodiesterase 6B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane
	Molecular Function	Catalytic Activity Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Galactoside Binding Galactosylgalactosylglucosylceramidase Activity Protein Homodimerization Activity Raffinose Alpha-galactosidase Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Oligosaccharide Metabolic Process Glycoside Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity	Signal Transduction Visual Perception Phototransduction, Visible Light Entrainment Of Circadian Clock By Photoperiod Retina Development In Camera-type Eye Retinal Cell Apoptotic Process
Pathways		Glycosphingolipid metabolism Neutrophil degranulation	Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway
Drugs		Migalastat	Caffeine Trapidil
Diseases
GWAS
Interacting Genes		14 interacting genes: ANKRD30A CCR2 COL4A5 DUSP6 GPR17 GUCY2F HNRNPH2 MORF4L2 NAP1L3 NOSTRIN OGT PDE6B PLP1 TERT	2 interacting genes: GLA THTPA
Entrez ID		2717	5158
HPRD ID		02357	01571
Ensembl ID		ENSG00000102393	ENSG00000133256
Uniprot IDs		P06280 Q53Y83	B4DHV7 P35913
PDB IDs		1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT
Enriched GO Terms of Interacting Partners?
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