UQCRQ and ERCC8

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		UQCRQ	ERCC8
Description		ubiquinol-cytochrome c reductase complex III subunit VII	ERCC excision repair 8, CSA ubiquitin ligase complex subunit
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function		Ubiquitin-protein Transferase Activity Protein Binding Protein-containing Complex Binding
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Subthalamus Development Pons Development Cerebellar Purkinje Cell Layer Development Hippocampus Development Thalamus Development Hypothalamus Development Pyramidal Neuron Development Midbrain Development	Single Strand Break Repair Protein Polyubiquitination Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Response To UV Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Regulation Of Transcription-coupled Nucleotide-excision Repair Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways		Respiratory electron transport	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases
GWAS		Asthma ( 31619474)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: ERCC6 ERCC8 JADE2 OPTN POLR2M	12 interacting genes: ADAMTS6 CAMK2D CBR1 CSNK2B CUL4B DDB1 ERCC6 GTF2H2 RBX1 TOP1 UQCRQ XAB2
Entrez ID		27089	1161
HPRD ID		17941	07523
Ensembl ID		ENSG00000164405	ENSG00000049167
Uniprot IDs		O14949	A0A0S2Z3L1 B3KPW7 B4DGZ9 Q13216
PDB IDs		5XTE 5XTH 5XTI	4A11 6FCV
Enriched GO Terms of Interacting Partners?
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