GJB2 and CD14

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		GJB2	CD14
Description		gap junction protein beta 2	CD14 molecule
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Integral Component Of Plasma Membrane Gap Junction Connexin Complex Lateral Plasma Membrane Cell Body Perinuclear Region Of Cytoplasm Astrocyte Projection	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome
	Molecular Function	Gap Junction Channel Activity Calcium Ion Binding Protein Binding Identical Protein Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling	Lipopolysaccharide Binding Opsonin Receptor Activity Protein Binding Peptidoglycan Immune Receptor Activity Lipoteichoic Acid Binding Lipopeptide Binding
	Biological Process	Response To Ischemia Cell-cell Signaling Aging Sensory Perception Of Sound Cell Communication By Electrical Coupling Gap Junction Assembly Response To Estradiol Response To Lipopolysaccharide Response To Retinoic Acid Response To Progesterone Cellular Response To Oxidative Stress Response To Human Chorionic Gonadotropin Response To Antibiotic Decidualization Inner Ear Development Transmembrane Transport Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Epididymis Development Gap Junction-mediated Intercellular Transport	Receptor-mediated Endocytosis Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Heat Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor Innate Immune Response Response To Ethanol Positive Regulation Of Endocytosis Response To Electrical Stimulus Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly Transport of connexons to the plasma membrane	ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Facial emotion recognition (happy faces) ( 28608620)	Blood protein levels ( 30072576) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)
Interacting Genes		44 interacting genes: AMIGO1 APLNR AQP6 ARL13B CAV1 CD14 CNST CREB3 EBP ERGIC3 FAM209A FFAR2 GJA5 GJA8 GJB1 GJB6 GPR152 GPR42 HSD17B13 KCNK5 KLRC1 LHFPL5 LMNA LRRC4C MFSD6 MS4A6E NGLY1 PEX12 PLEKHB2 SAR1A SHISAL1 SLC18A1 SLC30A2 SSMEM1 TBXA2R TEX29 TIMMDC1 TLCD4 TM2D2 TMEM106A TMEM237 TMEM31 TMX2 TRHR	15 interacting genes: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 REEP5 TLR2 TLR3 TLR4 TNFRSF1B
Entrez ID		2706	929
HPRD ID		00413	01151
Ensembl ID		ENSG00000165474	ENSG00000170458
Uniprot IDs		H9U1J4 P29033	P08571
PDB IDs		1XIR 2ZW3 3IZ1 3IZ2 5ER7 5ERA 5KJ3 5KJG 6UVR 6UVS 6UVT	4GLP
Enriched GO Terms of Interacting Partners?
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