LAT and GJB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LAT	GJB3
Description		linker for activation of T cells	gap junction protein beta 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Membrane Raft	Cytoplasm Gap Junction Connexin Complex Integral Component Of Membrane Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity	Gap Junction Channel Activity Protein Binding
	Biological Process	Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity Regulation Of T Cell Activation	In Utero Embryonic Development Placenta Development Cell-cell Signaling Spermatogenesis Skin Development Transmembrane Transport Cellular Response To Retinoic Acid
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules	Gap junction assembly
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)	Intraocular pressure ( 30591961) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		95 interacting genes: APH1A ASGR2 BCL2L13 BSCL2 CAMLG CBL CD244 CD3G CD4 CD53 CD8A CDIP1 CLDN2 CLDN5 CLDN7 CREB3 CXorf66 CYBC1 EGFR FCGR1A FCGR2A FFAR2 FFAR3 FKBP7 FYN GAB2 GJA8 GJB1 GJB3 GOLM1 GPR101 GPR151 GPR152 GPR42 GRAP GRAP2 GRB2 ITK JSRP1 KASH5 KCTD17 KIR2DL3 LCK LCP2 LEUTX LHFPL1 LHFPL5 LMNA MAP1LC3C MAP4K1 MEOX2 MFF MFSD14B MFSD5 MRPS18B MS4A7 MTIF3 NDUFAF2 OPRM1 PIK3R1 PLCG1 PLCG2 PRR4 PSCA PTPN1 PTPN6 PTPRJ SAR1A SERINC2 SGTA SGTB SH3BP2 SHB SLA SLC14A2 SLC16A2 SLC18A1 SLC19A3 SLC26A6 SLC35C2 SLC51B SLPI SSMEM1 SYK SYT2 THAP4 TM4SF18 TMEM237 TMEM45B TMEM80 TNFRSF10D VAV1 ZAP70 ZDHHC7 ZHX2	16 interacting genes: BTN2A2 CNST COMT ELAVL1 GIMAP5 IGFBP5 LAT LHFPL5 MFSD11 RPRM SERP1 TJP1 TMEM97 TMUB2 TRARG1 TUBD1
Entrez ID		27040	2707
HPRD ID		03832	04505
Ensembl ID		ENSG00000213658	ENSG00000188910
Uniprot IDs		A0A024QZD6 O43561	A0A654ICK0 O75712
PDB IDs
Enriched GO Terms of Interacting Partners?
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