USP21 and SLF1

Number of citations of the paper that reports this interaction (PubMedID 27621083)
17

Data Source:
BioGRID (two hybrid)

		USP21	SLF1
Description		ubiquitin specific peptidase 21	SMC5-SMC6 complex localization factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleosome Nucleus Nucleoplasm Cytoplasm Centrosome Site Of Double-strand Break Nuclear Inclusion Body
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Neuron Projection Development Positive Regulation Of Transcription, DNA-templated	DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS
Interacting Genes		61 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CDC34 CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXM1 H2AC18 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2D1 UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350	2 interacting genes: SLF2 USP21
Entrez ID		27005	84250
HPRD ID		05291	08538
Ensembl ID		ENSG00000143258	ENSG00000133302
Uniprot IDs		Q9UK80	I6L9F1 Q9BQI6
PDB IDs		2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?
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