CKAP2 and UBE2C

Number of citations of the paper that reports this interaction (PubMedID 17339342)
14

Data Source:
BioGRID (enzymatic study)

		CKAP2	UBE2C
Description		cytoskeleton associated protein 2	ubiquitin conjugating enzyme E2 C
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Centrosome Cytosol Microtubule Microtubule Cytoskeleton	Ubiquitin Ligase Complex Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Plasma Membrane
	Molecular Function		Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin-like Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Mitotic Cytokinesis Apoptotic Process Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Transcription By RNA Polymerase II	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Exit From Mitosis Cell Division Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Height ( 31562340)
Interacting Genes		6 interacting genes: AGR2 FBXO7 LRRK1 TSC22D1 UBE2C YWHAG	25 interacting genes: ANAPC11 ANAPC2 AURKA CDC20 CKAP2 CXCR1 DTX1 ENO2 ITCH KLHL2 MAPK7 PCGF3 POLM PRKN PSMD4 RAG1 RELA RNF31 TNNC1 TRIM21 TRIM28 TRIM29 UBA1 UBASH3B UBE3D
Entrez ID		26586	11065
HPRD ID		10832	05717
Ensembl ID		ENSG00000136108	ENSG00000175063
Uniprot IDs		Q8WWK9	A0A087WVK1 A0A0A0MSE8 O00762 Q5TZN3
PDB IDs			1I7K 4YII 5A31 5KHR 5L9U
Enriched GO Terms of Interacting Partners?
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