NR6A1 and UIMC1

Number of citations of the paper that reports this interaction (PubMedID 17416745)
43

Data Source:
HPRD (two hybrid, in vitro)

		NR6A1	UIMC1
Description		nuclear receptor subfamily 6 group A member 1	ubiquitin interaction motif containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex	Nucleus Nucleoplasm Nuclear Body BRCA1-A Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Protein Binding Histone Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Gamete Generation Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Double-strand Break Repair Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Histone H2A K63-linked Deubiquitination
Pathways			Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Menarche (age at onset) ( 27182965)	Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201 26414677 29773799) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: DNMT3L GNB5 NCOA1 NCOR1 NSD1 UIMC1	23 interacting genes: ABRAXAS1 ATP8A2 BRCC3 CEP57 CREBBP DVL2 DYNLT3 ECPAS ESR1 FANCG H2AC20 INO80B MDC1 NR6A1 RAD23A SKIL SUMO2 TP53 UBB UBC USP13 WBP2 ZMYM3
Entrez ID		2649	51720
HPRD ID		04147	11482
Ensembl ID		ENSG00000148200	ENSG00000087206
Uniprot IDs		F1D8S0 F1DAM1 Q15406	A0A024R7R0 Q96RL1
PDB IDs			2MKF 2MKG 2N9E 2RR9
Enriched GO Terms of Interacting Partners?
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