GCG and MEP1B

Number of citations of the paper that reports this interaction (PubMedID 11278902)
44

Data Source:
HPRD (in vitro)

		GCG	MEP1B
Description		glucagon	meprin A subunit beta
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Lumen	Extracellular Region Integral Component Of Plasma Membrane Meprin A Complex
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Glucagon Receptor Binding Identical Protein Binding	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Protein Kinase A Signaling Positive Regulation Of Peptidyl-threonine Phosphorylation Response To Activity Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis	Proteolysis Inflammatory Response Toxin Transport
Pathways		Glucagon signaling in metabolic regulation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors Synthesis, secretion, and deacylation of Ghrelin ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)	Metabolite levels ( 23823483) TRAIL levels ( 27989323)
Interacting Genes		8 interacting genes: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B RRM2	12 interacting genes: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT
Entrez ID		2641	4225
HPRD ID		00676	02667
Ensembl ID		ENSG00000115263	ENSG00000141434
Uniprot IDs		P01275	J3QKX5 Q16820
PDB IDs		1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL 4APD 4ZGM 5OTU 5OTV 5OTW 5OTX 5VAI 5YQZ 6EDS 6LMK 6LML 6NZN 6PHI 6PHJ 6PHK 6PHL 6PHO 6PHP 6VCB 6X18 7D68	4GWM 4GWN 7AQ1
Enriched GO Terms of Interacting Partners?
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