GBP3 and MAP4K4

Number of citations of the paper that reports this interaction (PubMedID 12387898)
2

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		GBP3	MAP4K4
Description		guanylate binding protein 3	mitogen-activated protein kinase kinase kinase kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Focal Adhesion
	Molecular Function	GTPase Activity Protein Binding GTP Binding Identical Protein Binding Protein Homodimerization Activity	Creatine Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Protein Serine Kinase Activity
	Biological Process	Defense Response To Virus Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	MAPK Cascade Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Microvillus Assembly Positive Regulation Of Cell Migration Positive Regulation Of ARF Protein Signal Transduction Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Neuron Projection Regeneration Positive Regulation Of Focal Adhesion Disassembly
Pathways		Interferon gamma signaling	Oxidative Stress Induced Senescence
Drugs			Fostamatinib
Diseases
GWAS		Carotid intima media thickness ( 26343869)	Alzheimer's disease ( 30636644) Asthma ( 31619474) Asthma (time to onset) ( 27130862) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: LRRC8B MAP4K4	18 interacting genes: BRCA1 CASP8 DOK1 GBP3 H2BC21 ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2
Entrez ID		2635	9448
HPRD ID		02683	05235
Ensembl ID		ENSG00000117226	ENSG00000071054
Uniprot IDs		Q9H0R5	B7Z3V5 O95819 V9HWH3
PDB IDs			4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q
Enriched GO Terms of Interacting Partners?
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