EHF and GDF15

		EHF	GDF15
Description		ETS homologous factor	growth differentiation factor 15
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Golgi Apparatus	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity BMP Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Multicellular Organism Development Cell Differentiation Epithelial Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cell Proliferation	Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion
Pathways
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cystic fibrosis severity ( 21602797) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung disease severity in cystic fibrosis ( 26417704) Obesity-related traits ( 23251661) Prostate-specific antigen levels ( 28139693) Response to antipsychotic treatment ( 21107309) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Systemic lupus erythematosus ( 24871463) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Volumetric brain MRI ( 17903297)	Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		4 interacting genes: APP FRZB GDF15 TRAF6	20 interacting genes: ALOX5AP BORCS8-MEF2B BRME1 CBX3 COPE EHF FCHO1 HOMER3 HOXA1 IL27RA KRTAP12-2 MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1 TACC3
Entrez ID		26298	9518
HPRD ID		16105	05608
Ensembl ID		ENSG00000135373	ENSG00000130513
Uniprot IDs		Q9NZC4	Q99988
PDB IDs			5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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