SACS and CD83

		SACS	CD83
Description		sacsin molecular chaperone	CD83 molecule
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Axon Dendrite Cell Body Fiber	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Hsp70 Protein Binding Chaperone Binding Proteasome Binding	Protein Binding
	Biological Process	Protein Folding Negative Regulation Of Inclusion Body Assembly	Defense Response Humoral Immune Response Signal Transduction Response To Organic Cyclic Compound Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Blood pressure (smoking interaction) ( 25189868) Hypothyroidism ( 22493691) Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 23300278)	Breast cancer and/or colorectal cancer ( 29698419) California verbal learning test score ( 31596458) Chronotype ( 30696823) Obesity-related traits ( 23251661) Response to tofacitinib treatment (herpes zoster) ( 33455090) Response to tofacitinib treatment (herpes zoster)(time to event) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) ( 33455090) Rheumatoid arthritis ( 30423114 22446963 24390342)
Interacting Genes		7 interacting genes: ACTN4 ADRB2 CD83 PICK1 POLR1H TSC22D4 UBE3A	10 interacting genes: EIF4E FAM8A1 FATE1 GCM2 GMPR KIF13A NOL7 PAPSS2 SACS SPP1
Entrez ID		26278	9308
HPRD ID		05135	05170
Ensembl ID		ENSG00000151835	ENSG00000112149
Uniprot IDs		Q9NZJ4	A0A087WX61 Q01151
PDB IDs		1IUR 3O10 5V44 5V45 5V46 5VSX 5VSZ	5MIX 5MJ0 5MJ1 5MJ2
Enriched GO Terms of Interacting Partners?
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