FBXO5 and ANAPC1

Number of citations of the paper that reports this interaction (PubMedID 16921029)
95

Data Source:
BioGRID (affinity chromatography technology, pull down)

		FBXO5	ANAPC1
Description		F-box protein 5	anaphase promoting complex subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Meiotic Spindle	Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Protein Kinase Binding Metal Ion Binding Ubiquitin Ligase Inhibitor Activity	Molecular Adaptor Activity
	Biological Process	Oocyte Maturation Regulation Of DNA Replication Spindle Assembly Involved In Female Meiosis I Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle Organization Protein Ubiquitination Negative Regulation Of DNA Endoreduplication Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Polymerization Cell Division Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Biomineral Tissue Development Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Mesenchymal Stem Cell Migration Negative Regulation Of Cellular Senescence Negative Regulation Of Response To DNA Damage Stimulus	Metaphase/anaphase Transition Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Cell Division Protein K11-linked Ubiquitination
Pathways		SCF-beta-TrCP mediated degradation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Mitotic Metaphase/Anaphase Transition G1/S-Specific Transcription	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Prostate cancer ( 23535732)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 23817571) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Corneal endothelial cell density ( 30894546) Corneal hysteresis ( 31246245 32716492 30894546) Corneal resistance factor ( 31246245 32716492 30894546) Femoral neck bone mineral density ( 22504420) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) Intraocular pressure ( 29785010 30054594) Obesity-related traits ( 23251661)
Interacting Genes		13 interacting genes: ANAPC1 ANAPC11 ANAPC5 ANAPC7 CDC16 CDC20 CDC23 CDK1 EVI5 FZR1 SKP1 SRC TPM3	9 interacting genes: CDC20 FBXO5 FZR1 HRAS MDC1 SUMO2 UBC UBE2S WBP2
Entrez ID		26271	64682
HPRD ID		09348	09769
Ensembl ID		ENSG00000112029	ENSG00000153107
Uniprot IDs		Q9UKT4	Q9H1A4
PDB IDs		2M6N 4UI9	4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 5LGG 6Q6G 6Q6H 6TLJ 6TM5 6TNT
Enriched GO Terms of Interacting Partners?
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