GATA6 and NKX2-1

Number of citations of the paper that reports this interaction (PubMedID 11733512)
30

Data Source:
HPRD (in vitro, two hybrid)

		GATA6	NKX2-1
Description		GATA binding protein 6	NK2 homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Membrane	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Liver Development Sebaceous Gland Cell Differentiation Regulation Of Antimicrobial Humoral Response Outflow Tract Septum Morphogenesis Atrioventricular Node Development Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Regulation Of Transcription By RNA Polymerase II Phospholipid Metabolic Process Endodermal Cell Fate Determination Male Gonad Development Response To Xenobiotic Stimulus Cardiac Muscle Hypertrophy In Response To Stress Epithelial Cell Differentiation Response To Retinoic Acid Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta2 Production Tube Morphogenesis Atrioventricular Canal Development Negative Regulation Of Apoptotic Process Response To Estrogen Cell Fate Commitment Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Formation Smooth Muscle Cell Differentiation Regulation Of Cell Cycle Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Lung Saccule Development Club Cell Differentiation Type II Pneumocyte Differentiation Intestinal Epithelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Response To Growth Factor Cellular Response To Gonadotropin Stimulus Cellular Response To Hypoxia Cellular Response To BMP Stimulus Skin Epidermis Development Positive Regulation Of Cardiac Muscle Myoblast Proliferation Positive Regulation Of Transforming Growth Factor Beta Activation Negative Regulation Of Sebum Secreting Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of Transcription By RNA Polymerase II Phospholipid Metabolic Process Axon Guidance Brain Development Endoderm Development Locomotory Behavior Response To Hormone Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Globus Pallidus Development Hippocampus Development Cerebral Cortex Cell Migration Forebrain Dorsal/ventral Pattern Formation Forebrain Neuron Fate Commitment Cerebral Cortex GABAergic Interneuron Differentiation Pituitary Gland Development Cell Differentiation Lung Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Forebrain Development Developmental Induction Leydig Cell Differentiation Positive Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Anatomical Structure Formation Involved In Morphogenesis Oligodendrocyte Differentiation Lung Saccule Development Epithelial Tube Branching Involved In Lung Morphogenesis Club Cell Differentiation Type II Pneumocyte Differentiation
Pathways		Surfactant metabolism Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) LDL cholesterol ( 25961943) Lung function (FEV1/FVC) ( 30804560) Resting heart rate ( 27798624) Severe progression in rheumatoid arthritis ( 29065906) Tuberculosis ( 20694014)	Differentiated thyroid cancer ( 28703219) Height ( 18391950) Menarche (age at onset) ( 23667675 29773799) Papillary thyroid cancer ( 28703219) Thyroid cancer ( 19198613)
Interacting Genes		9 interacting genes: CRIP2 EP300 FOXJ1 HHEX KLF2 KPNA3 MED1 NKX2-1 OGT	16 interacting genes: CALR CAVIN1 CREBBP FOXA1 GATA6 HIPK2 JAKMIP1 MAPK1 NCOA1 NCOA2 NCOA3 PAX8 RARA RELA TDG WWTR1
Entrez ID		2627	7080
HPRD ID		09043	02798
Ensembl ID		ENSG00000141448	ENSG00000136352
Uniprot IDs		Q92908	P43699
PDB IDs
Enriched GO Terms of Interacting Partners?
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