GATA4 and NFATC4

Number of citations of the paper that reports this interaction (PubMedID 9568714)
677

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		GATA4	NFATC4
Description		GATA binding protein 4	nuclear factor of activated T cells 4
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Transcription Regulator Complex Cytosol Nuclear Speck
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Sequence-specific DNA Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Co-SMAD Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Peroxisome Proliferator Activated Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Heart Looping Atrioventricular Node Development Aortic Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Endoderm Development Male Gonad Development Response To Xenobiotic Stimulus Response To Mechanical Stimulus Negative Regulation Of Autophagy Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of BMP Signaling Pathway Response To Vitamin A Embryonic Heart Tube Anterior/posterior Pattern Specification Atrioventricular Canal Development Wound Healing Cell Fate Commitment Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Foregut Morphogenesis Positive Regulation Of Cardioblast Differentiation Regulation Of Protein Kinase B Signaling Transdifferentiation Atrial Septum Morphogenesis Intestinal Epithelial Cell Differentiation Cardiac Muscle Tissue Regeneration Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Apoptotic Signaling Pathway	Branching Involved In Blood Vessel Morphogenesis Cytokine Production Regulation Of Transcription By RNA Polymerase II Inflammatory Response Heart Development Long-term Memory Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Wnt Signaling Pathway Brain-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Tumor Necrosis Factor Production Calcineurin-NFAT Signaling Cascade Cellular Response To UV Negative Regulation Of Chromatin Binding Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Dendrite Morphogenesis Smooth Muscle Cell Differentiation Muscle Cell Development Long-term Synaptic Potentiation Cellular Response To Lithium Ion Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Synapse Maturation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Physiological factors Transcriptional regulation of testis differentiation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Atrial fibrillation ( 30061737 29892015) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Left ventricular global circumferential strain (MTAG) ( 33495596) Left ventricular global longitudinal strain (MTAG) ( 33495596) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myopia (pathological) ( 23049088) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Retinal vascular caliber ( 21060863) Systolic blood pressure ( 28135244 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Testicular germ cell tumor ( 28604728) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Diastolic blood pressure ( 27841878) Height ( 20881960 25282103 23563607) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		24 interacting genes: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 RACK1 SP1 SRF TBX5 ZBTB3 ZFPM2	12 interacting genes: CCNG1 CREBBP GATA4 GPR22 JUP MAPK14 MAPK8 MAPK9 NLGN3 NR1I2 YWHAQ YWHAZ
Entrez ID		2626	4776
HPRD ID		08994	09096
Ensembl ID		ENSG00000136574	ENSG00000100968
Uniprot IDs		B3KUF4 B6DU75 P43694	Q14934
PDB IDs		2M9W	2YRP
Enriched GO Terms of Interacting Partners?
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