GATA2 and KRTAP3-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GATA2	KRTAP3-1
Description		GATA binding protein 2	keratin associated protein 3-1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm	Cytosol Keratin Filament
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding	Structural Molecule Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Cell Fate Determination Neuron Migration Embryonic Placenta Development Regulation Of Transcription By RNA Polymerase II Phagocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Primitive Erythrocyte Differentiation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Pituitary Gland Development Response To Lipid Somatic Stem Cell Population Maintenance Regulation Of Histone Acetylation Eosinophil Fate Commitment Inner Ear Morphogenesis Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Positive Regulation Of Phagocytosis, Engulfment Definitive Hemopoiesis Semicircular Canal Development Vascular Wound Healing Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cochlea Development GABAergic Neuron Differentiation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Forebrain Neuron Differentiation
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production	Keratinization
Drugs
Diseases
GWAS		Basophil count ( 28031487) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) Eosinophil counts ( 19198610) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Preterm birth (maternal effect) ( 28877031) Prostate cancer ( 31562322) Pulse pressure ( 28135244 27841878 30578418) Systolic blood pressure ( 27841878) White blood cell count ( 21738480) White blood cell count (basophil) ( 28158719) White blood cell count (eosinophil) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		46 interacting genes: ADAMTSL4 AKT1 CDK1 CEBPA CYSRT1 EP300 FBXW7 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 KRTAP11-1 KRTAP13-3 KRTAP21-2 KRTAP3-1 KRTAP6-3 KRTAP7-1 KRTAP8-1 LMO2 MAPK1 MDFI MSX2 NOTCH2NLA PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RBPMS RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1	82 interacting genes: ADAM12 AGXT ANAPC11 BMP7 C20orf85 CDKN1A CELA2B CERK CFP CNNM3 CREB5 CTRC CYSRT1 DMRT3 DOCK2 FAM168A FAM222B FOXH1 FRS3 GATA2 GNE GPS2 GSTP1 HCK HEY2 HOXB9 HR HSF4 IL16 ITGB4 KRTAP10-8 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP6-1 KRTAP9-3 KRTAP9-8 LCE1B LCE2B LCE3A LCE3D LCE4A LCE5A LMO4 LRRC41 MAPKBP1 MRPL40 MYPOP NOTCH2NLA NTAQ1 OTX1 PATZ1 PCSK5 PHLDA1 PKIB PLSCR4 POLR1C PPP1R32 PTPMT1 PVR RBPMS RECK REEP6 RNF44 SAMD7 SMARCC1 SPAG8 TEKT3 TEX37 TLX3 TNS2 VASN VENTX VGLL3 WDR25 YPEL3 ZFHX2 ZNF414 ZNF446
Entrez ID		2624	83896
HPRD ID		00673	13937
Ensembl ID		ENSG00000179348	ENSG00000212901
Uniprot IDs		P23769	Q9BYR8
PDB IDs		5O9B
Enriched GO Terms of Interacting Partners?
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