FBXL6 and ETV6

Number of citations of the paper that reports this interaction (PubMedID 18426905)
11

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		FBXL6	ETV6
Description		F-box and leucine rich repeat protein 6	ETS variant transcription factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol SCF Ubiquitin Ligase Complex	Chromatin Nucleus Nucleolus Cytosol Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Proteolysis Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Vitellogenesis Neurogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Proliferation Mesenchymal Cell Apoptotic Process
Pathways			Signaling by membrane-tethered fusions of PDGFRA or PDGFRB Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Asthma ( 27611488) Body size at age 10 ( 32376654) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Colorectal cancer ( 27145994) Eye color ( 33692100) Height ( 28552196 20881960 25282103 23563607 31562340 18391951) Hematocrit ( 32888494) Hemoglobin ( 32888494) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Night sleep phenotypes ( 27126917) Phosphorus levels ( 29403010) Red blood cell count ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		2 interacting genes: ETV6 TSC2	21 interacting genes: AP1M1 AXIN1 CD27 CRKL FBXL6 FLI1 GAB2 GRB2 HDAC9 KAT5 L3MBTL1 NFE2L2 NSD3 NTAQ1 PIN1 SIN3A SMURF1 SUMO1 TRAF2 TUBA4A UBE2I
Entrez ID		26233	2120
HPRD ID		16429	15976
Ensembl ID		ENSG00000182325	ENSG00000139083
Uniprot IDs		Q8N531	A0A0S2Z3C9 P41212
PDB IDs			1JI7 1LKY 2DAO 2QAR 2QB0 2QB1 5L0P 7JU2
Enriched GO Terms of Interacting Partners?
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