EPC2 and FAP

		EPC2	FAP
Description		enhancer of polycomb homolog 2	fibroblast activation protein alpha
Image		No pdb structure
GO Annotations	Cellular Component	Piccolo NuA4 Histone Acetyltransferase Complex	Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Lamellipodium Lamellipodium Membrane Ruffle Membrane Apical Part Of Cell Basal Part Of Cell Peptidase Complex
	Molecular Function	Histone Acetyltransferase Activity	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	DNA Repair Regulation Of Transcription By RNA Polymerase II Histone Acetylation	Angiogenesis Proteolysis Cell Adhesion Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Endothelial Cell Migration Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Cycle Regulation Of Fibrinolysis Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Melanocyte Proliferation Positive Regulation Of Execution Phase Of Apoptosis Melanocyte Apoptotic Process Negative Regulation Of Extracellular Matrix Organization
Pathways
Drugs			Sibrotuzumab
Diseases
GWAS		Alzheimer's disease biomarkers ( 21123754) Chronotype ( 30696823) Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913) Pulse pressure ( 30578418) Relative amplitude of rest-activity cycles ( 30120083) Schizophrenia ( 29483656 30285260) Type 2 diabetes ( 32499647 30718926)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Inflammatory skin disease ( 25574825) Medication use (thyroid preparations) ( 31015401) Regular attendance at a pub or social club ( 29970889) Systemic lupus erythematosus ( 33272962 28714469)
Interacting Genes		5 interacting genes: EED EZH2 FAP MMADHC NMI	4 interacting genes: DPP4 EPC2 NR4A2 PLAUR
Entrez ID		26122	2191
HPRD ID		13274	02674
Ensembl ID		ENSG00000135999	ENSG00000078098
Uniprot IDs		Q52LR7	B4DLR2 Q12884
PDB IDs			1Z68 6Y0F
Enriched GO Terms of Interacting Partners?
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