WIPI2 and RPTOR

Number of citations of the paper that reports this interaction (PubMedID 30340022)
18

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		WIPI2	RPTOR
Description		WD repeat domain, phosphoinositide interacting 2	regulatory associated protein of MTOR complex 1
Image		No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleoplasm Autophagosome Cytosol Membrane Extrinsic Component Of Membrane Protein-containing Complex Phagophore Assembly Site Membrane	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Dendrite TORC1 Complex Neuronal Cell Body
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein-macromolecule Adaptor Activity Protein-containing Complex Binding 14-3-3 Protein Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Protein Lipidation Cellular Response To Starvation Protein Localization To Phagophore Assembly Site Autophagy Of Nucleus Protein Lipidation Involved In Autophagosome Assembly Autophagosome Maturation Xenophagy	Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell Size Cellular Response To Starvation Response To Xenobiotic Stimulus Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Social Behavior TORC1 Signaling Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Macroautophagy	Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Bone mineral density x blood lead interaction in current smokers (1df test) ( 29518117) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Red blood cell count ( 32888494)	Adult body size ( 32376654) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Nicotine dependence symptom count ( 25555482) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)
Interacting Genes		16 interacting genes: ARL6IP1 COPS6 DDB1 DGAT2L6 FKBP7 HUWE1 MRRF MTOR OPTN POT1 RABAC1 REEP6 RPTOR STRN4 SYP TERF2IP	30 interacting genes: BAHCC1 CBX8 CCDC40 CILK1 DCXR DUXAP9 EIF4EBP1 EIF4EBP2 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NRBF2 PLD2 PRKAA1 PRKAA2 RAP1B RHEB RNF213 RPS6KA1 RPS6KB1 RRAGB TNRC6C USP36 WDR45B WIPI2
Entrez ID		26100	57521
HPRD ID		15679	06184
Ensembl ID		ENSG00000157954	ENSG00000141564
Uniprot IDs		A0A024R823 Q9Y4P8	Q6DKI0 Q8N122
PDB IDs			5H64 6BCU 6BCX 6SB0 6SB2 6U62
Enriched GO Terms of Interacting Partners?
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