ERC2 and HNF1B

		ERC2	HNF1B
Description		ELKS/RAB6-interacting/CAST family member 2	HNF1 homeobox B
Image		No pdb structure
GO Annotations	Cellular Component	Growth Cone Presynaptic Membrane Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Structural Constituent Of Presynaptic Active Zone	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Neuromuscular Synaptic Transmission Synaptic Vesicle Priming Regulation Of Synaptic Plasticity Maintenance Of Presynaptic Active Zone Structure	Kidney Development Regulation Of Transcription By RNA Polymerase II Response To Xenobiotic Stimulus Response To Carbohydrate Response To Organic Cyclic Compound Insulin Secretion Pancreas Development Circadian Regulation Of Gene Expression Regulation Of Pronephros Size Pronephric Nephron Tubule Development Positive Regulation Of Transcription, DNA-templated Embryonic Morphogenesis Pronephros Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Protein-DNA Complex Assembly Hepatocyte Differentiation
Pathways			Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Regulation of gene expression in early pancreatic precursor cells
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Adult body size ( 32376654) Alcohol dependence ( 24166409) Bipolar disorder and schizophrenia ( 21057379) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549 28869591) Hip bone size ( 31053729) Hip circumference adjusted for BMI ( 34021172) Hip geometry ( 17903296) Intertrochanteric region size ( 31053729) Lateral thalamic nuclei volume ( 34006833) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Morning vs. evening chronotype ( 26955885 27494321) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Sense of smell ( 26632684) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990) Trochanter size ( 31053729)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 28892062) C-reactive protein levels ( 33339817) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Endometrial cancer ( 30093612 27008869 21499250 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Epithelial ovarian cancer ( 25581431) Frontotemporal dementia ( 26154020) Gallstone disease ( 30504769) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Medication use (drugs used in diabetes) ( 31015401) Neuritic plaque ( 25188341) Ovarian cancer ( 23535730) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Prostate cancer ( 20676098 18264096 18264097 30410027 31562322 25939597 34012061 26443449 27262462) Prostate-specific antigen levels ( 30410027 28139693) Serum prostate-specific antigen levels ( 21160077) Testicular germ cell tumor ( 25877299 28604728 28604732) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 23945395 22961080 32499647 20581827 30718926 28869590)
Interacting Genes		9 interacting genes: BSN HNF1B MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1	22 interacting genes: ALDOC ASGR2 ATF1 BPIFA1 C10orf55 CDK5R1 CREB1 CREBBP CRX ERC2 H3C1 HNF1A KRTAP26-1 MLLT10 OTX2 OXER1 PARD3 PCBD1 POU6F2 UFSP1 USP54 VAC14
Entrez ID		26059	6928
HPRD ID		10810	08926
Ensembl ID		ENSG00000187672	ENSG00000275410
Uniprot IDs		O15083	A0A087WZC2 A0A0C4DGS8 E0YMJ6 P35680 Q6FHW6
PDB IDs			2DA6 2H8R 5K9S
Enriched GO Terms of Interacting Partners?
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