CNTNAP2 and CNTN2

Number of citations of the paper that reports this interaction (PubMedID 12975355)
83

Data Source:
HPRD (in vitro)

		CNTNAP2	CNTN2
Description		contactin associated protein 2	contactin 2
Image
GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Voltage-gated Potassium Channel Complex Cell Surface Membrane Integral Component Of Membrane Axon Dendrite Axolemma Paranodal Junction Neuronal Cell Body Perikaryon Juxtaparanode Region Of Axon	Plasma Membrane Cell Surface Axon Node Of Ranvier Neuronal Cell Body Myelin Sheath Juxtaparanode Region Of Axon Synapse Anchored Component Of Postsynaptic Membrane
	Molecular Function	Protein Binding Enzyme Binding	Protein Binding Carbohydrate Binding Identical Protein Binding Protein Self-association Cell-cell Adhesion Mediator Activity
	Biological Process	Cell Adhesion Brain Development Learning Neuron Recognition Transmission Of Nerve Impulse Striatum Development Limbic System Development Thalamus Development Cerebral Cortex Development Adult Behavior Neuron Projection Development Social Behavior Vocal Learning Clustering Of Voltage-gated Potassium Channels Neuron Projection Morphogenesis Superior Temporal Gyrus Development Protein Localization To Juxtaparanode Region Of Axon Vocalization Behavior Positive Regulation Of Gap Junction Assembly	Microtubule Cytoskeleton Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Axonal Fasciculation Learning Adult Walking Behavior Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Processing Cerebral Cortex GABAergic Interneuron Migration Central Nervous System Myelination Regulation Of Axon Diameter Receptor Internalization Clustering Of Voltage-gated Potassium Channels Negative Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Astrocyte Differentiation Positive Regulation Of Adenosine Receptor Signaling Pathway Dendrite Self-avoidance Protein Localization To Juxtaparanode Region Of Axon Establishment Of Protein Localization To Juxtaparanode Region Of Axon Presynaptic Membrane Organization
Pathways			L1CAM interactions NCAM1 interactions NrCAM interactions
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Alzheimer's disease ( 22159054) Alzheimer's disease (late onset) ( 26049409) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimerâ€™s disease and/or vascular dementia (clinical subgroup VaD++) ( 31473137) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Bipolar disorder and schizophrenia ( 20889312) Bitter alcoholic beverage consumption ( 31046077) Blood protein levels ( 30072576 29875488) Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Bone mineral density ( 17903296) Choroid plexus volume ( 31530798) Chronic kidney disease (severe chronic kidney disease vs normal kidney function) in type 1 diabetes ( 27647854) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Crohn's disease ( 26192919) Diabetic kidney disease ( 26305897) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Family history of Alzheimer's disease ( 30617256) Ferritin levels ( 33491795) Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment ( 33608531) ghrelin levels ( 33852427) Glaucoma ( 30104761) Inflammatory bowel disease ( 26192919) Initial pursuit acceleration ( 29064472) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol x physical activity interaction (1df test) ( 30670697) LDL cholesterol x physical activity interaction (2df test) ( 30670697) Lung function (FEV1/FVC) ( 30061609) Obesity-related traits ( 23251661) Postprandial triglyceride response ( 32603185) QT interval (drug interaction) ( 23459443) Response to antiepileptic drugs in genetic generalized epilepsy ( 32308125) Response to radiotherapy in cancer (late toxicity) ( 24785509) Smoking status (heavy vs never) ( 26423011) Ulcerative colitis ( 26192919) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference ( 34074324)	Adventurousness ( 30643258) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576 29875488 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) HDL cholesterol levels ( 32203549) Mean platelet volume ( 24026423) Meat-related diet ( 32066663) Number of sexual partners ( 30643258) Periodontitis (stage III/IV grade C) ( 33745150) Red blood cell count ( 27863252) Schizophrenia ( 30285260) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: CASK CNTN2 CPE CTR9 EPB41L3 GORASP2 KCNA2 MACF1 MEOX2 POLR2G ZMIZ1	13 interacting genes: CDK4 CHEK1 CNTN1 CNTNAP2 EGFR L1CAM NCAN NEK2 NFYB NRCAM TUBG1 UBE4B VAC14
Entrez ID		26047	6900
HPRD ID		05197	01826
Ensembl ID		ENSG00000174469	ENSG00000184144
Uniprot IDs		A0A090N7T7 B2RCH4 Q9UHC6	A1L3A3 A1ML24 Q02246
PDB IDs		5Y4M	2OM5
Enriched GO Terms of Interacting Partners?
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