MTHFD1L and ARID1B

		MTHFD1L	ARID1B
Description		methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	AT-rich interaction domain 1B
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol Membrane	Nucleoplasm Cytosol Plasma Membrane SWI/SNF Complex Brahma Complex NBAF Complex
	Molecular Function	Formate-tetrahydrofolate Ligase Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity ATP Binding Protein Homodimerization Activity	DNA Binding Transcription Coactivator Activity Protein Binding Nucleosome Binding
	Biological Process	Neural Tube Closure Folic Acid-containing Compound Metabolic Process 10-formyltetrahydrofolate Biosynthetic Process Formate Metabolic Process Tetrahydrofolate Interconversion Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Transcription, DNA-templated Chromatin-mediated Maintenance Of Transcription
Pathways		Metabolism of folate and pterines	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 20885792) Chronic myeloid leukemia ( 21540461) Coronary heart disease ( 17634449) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Refractive error ( 32231278) Type 2 diabetes ( 25760438)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease biomarkers ( 23419831) Calcium levels ( 24068962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Iris color (b* coordinate) ( 30895295) Lipoprotein (a) levels ( 26377243) Low density lipoprotein cholesterol levels ( 30498476) Multiple system atrophy (pathologically confirmed) ( 27629089) Pancreatic cancer ( 22158540) Psychosis proneness (perceptual aberration scale and revised physical anhedonia scale) ( 28525603) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Type 2 diabetes ( 29621232) Vein graft stenosis in coronary artery bypass grafting ( 25881214) Western dietary pattern ( 28644415)
Interacting Genes		2 interacting genes: ARID1B HGS	15 interacting genes: ARMT1 CUL2 ENO1 GINM1 H2BC21 MAU2 MTHFD1L NCOA6 PLEKHG1 PYGM SMAD9 SMARCA2 SMARCA4 TNFRSF19 ZBTB2
Entrez ID		25902	57492
HPRD ID		09967	10660
Ensembl ID		ENSG00000120254	ENSG00000049618
Uniprot IDs		A0A087WVM4 B2RD24 B7ZM99 Q6UB35	Q8NFD5
PDB IDs			2CXY 2EH9
Enriched GO Terms of Interacting Partners?
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