SPEF1 and NKX2-2

		SPEF1	NKX2-2
Description		sperm flagellar 1	NK2 homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Microvillus Axoneme Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium Filopodium Ciliary Tip 9+2 Motile Cilium Axonemal Central Apparatus	Chromatin Nucleus Nucleoplasm
	Molecular Function	Molecular_function Actin Binding Protein Binding Microtubule Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Microtubule Bundle Formation Cilium Movement Negative Regulation Of Microtubule Depolymerization Cell Migration Lamellipodium Assembly Filopodium Assembly Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Death Axonemal Central Apparatus Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Brain Development Response To Glucose Positive Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Cell Differentiation Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Ventral Spinal Cord Interneuron Fate Determination
Pathways			Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal volume ( 29860282) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: CYSRT1 KIZ KRT40 KRTAP13-2 NKX2-2 PLEKHF2 ZBED1	7 interacting genes: CDK5RAP1 DLGAP4 KIZ OLIG2 RASSF2 RECQL SPEF1
Entrez ID		25876	4821
HPRD ID		09839	05213
Ensembl ID		ENSG00000101222	ENSG00000125820
Uniprot IDs		Q9Y4P9	O95096
PDB IDs		2EE7
Enriched GO Terms of Interacting Partners?
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