USP49 and NAMPT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		USP49	NAMPT
Description		ubiquitin specific peptidase 49	nicotinamide phosphoribosyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Cytosol Plasma Membrane Nuclear Speck Cell Junction Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Zinc Ion Binding Histone Binding	Nucleotide Binding Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Cytokine Activity Protein Binding Identical Protein Binding Nicotinamide Phosphoribosyltransferase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination	Microglial Cell Activation Signal Transduction Cell-cell Signaling Female Pregnancy Aging Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway NAD Biosynthetic Process Negative Regulation Of Autophagy Response To Organic Cyclic Compound Regulation Of Lung Blood Pressure Circadian Regulation Of Gene Expression NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Adipose Tissue Development Neuron Death Cellular Response To Ionizing Radiation Cellular Response To Oxygen-glucose Deprivation Cellular Response To Amyloid-beta Response To D-galactose Negative Regulation Of Cellular Senescence
Pathways		Ub-specific processing proteases	BMAL1:CLOCK,NPAS2 activates circadian gene expression Nicotinamide salvaging
Drugs			GMX1777 Daporinad
Diseases
GWAS		Cutaneous psoriasis ( 26626624) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 23263863 32888494 20139978 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494 20139978 27863252) Reticulocyte count ( 32888494) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)	Grapefruit juice consumption ( 31046077)
Interacting Genes		12 interacting genes: FKBP5 H2BC21 MED17 MED18 MED8 NAMPT PTCD2 RBCK1 STING1 TP53 TRIM35 ZNF774	7 interacting genes: ADORA2A AKT2 FANCA GGT1 LOX OGT USP49
Entrez ID		25862	10135
HPRD ID		10075	09938
Ensembl ID		ENSG00000164663	ENSG00000105835
Uniprot IDs		Q70CQ1	A0A024R718 P43490
PDB IDs			2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4LWW 4M6P 4M6Q 4N9B 4N9C 4N9D 4N9E 4O0Z 4O10 4O12 4O13 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28 4WQ6 5KIT 5LX3 5LX5 5NSD 5U2M 5U2N 5UPE 5UPF 5WI0 5WI1 6ATB 6AZJ 6B75 6B76 6E68 6PEB 6TA0 6TA2 6TAC
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?