YIPF3 and NGEF

		YIPF3	NGEF
Description		Yip1 domain family member 3	neuronal guanine nucleotide exchange factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Transport Vesicle Intracellular Membrane-bounded Organelle	Cytosol Membrane Growth Cone
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Cell Differentiation	Nervous System Development Cell Differentiation Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Activation Of GTPase Activity
Pathways			NRAGE signals death through JNK EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Contrast sensitivity ( 24152035) Heel bone mineral density ( 30598549 28869591) Parkinson's disease ( 32201043) Pursuit maintenance gain ( 29064472) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Sudden cardiac arrest ( 30169657) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		24 interacting genes: CHRM3 CHRM4 DRD2 HOXA1 HRH1 INCA1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP3-2 KRTAP5-9 KRTAP9-4 KRTAP9-8 MC4R NGEF NOTCH2NLA OPRM1 OXTR PLSCR1 TRIM42 YIPF4	18 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK MRPL44 NUDT21 RHOA SEPTIN2 SH2D1A SMO TAF1D TRIM55 TRIM63 TTK USP25 YIPF3
Entrez ID		25844	25791
HPRD ID		09852	10442
Ensembl ID		ENSG00000137207	ENSG00000066248
Uniprot IDs		Q9GZM5	B4DDI2 Q8N5V2
PDB IDs
Enriched GO Terms of Interacting Partners?
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