HECTD1 and SCFD1

		HECTD1	SCFD1
Description		HECT domain E3 ubiquitin protein ligase 1	sec1 family domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component		Golgi Membrane Endoplasmic Reticulum Membrane Golgi-associated Vesicle Cis-Golgi Network Cytosol Plasma Membrane Golgi Cisterna Membrane
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Syntaxin Binding Protein-containing Complex Binding Protein N-terminus Binding
	Biological Process	Natural Killer Cell Differentiation Neural Tube Closure Heart Valve Development Ventricular Septum Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Anatomical Structure Development Protein Autoubiquitination Trophoblast Giant Cell Differentiation Protein K63-linked Ubiquitination Negative Regulation Of Protein Localization To Plasma Membrane	Cell Morphogenesis Response To Hypoxia Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Post-Golgi Vesicle-mediated Transport Response To Toxic Substance Vesicle-mediated Transport Regulation Of Protein Transport Regulation Of ER To Golgi Vesicle-mediated Transport Toxin Transport Negative Regulation Of Autophagosome Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	COPII-mediated vesicle transport RHOA GTPase cycle
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 29566793 27455348) Cognitive decline (age-related) ( 28078323) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		10 interacting genes: HRAS HSPB1 IGSF1 KHNYN MTNR1B SCFD1 UBE2D2 UBE2D3 UBE2L3 YWHAG	6 interacting genes: DLST HECTD1 PPBP STX5 USO1 USP22
Entrez ID		25831	23256
HPRD ID		17098	10210
Ensembl ID		ENSG00000092148	ENSG00000092108
Uniprot IDs		Q9ULT8	A0A7I2V362 B7Z5N7 B7Z738 Q8WVM8
PDB IDs		2DK3 2LC3 3DKM
Enriched GO Terms of Interacting Partners?
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