SHC2 and NTRK3

Number of citations of the paper that reports this interaction (PubMedID 12006576)
13

Data Source:
HPRD (in vivo, two hybrid)

		SHC2	NTRK3
Description		SHC adaptor protein 2	neurotrophic receptor tyrosine kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Axon Receptor Complex Glutamatergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MAPK Cascade	Neuron Migration Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Heart Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Response To Ethanol Ephrin Receptor Signaling Pathway Neuron Fate Specification Response To Axon Injury Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Positive Chemotaxis Response To Corticosterone Regulation Of Protein Kinase B Signaling Negative Regulation Of Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cochlea Development Activation Of GTPase Activity Regulation Of Postsynaptic Density Assembly Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Signalling to RAS Signalling to RAS VEGFA-VEGFR2 Pathway RAF/MAP kinase cascade	Receptor-type tyrosine-protein phosphatases NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor
Drugs			Entrectinib Fostamatinib Larotrectinib Pralsetinib
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Gaucher disease severity ( 22388998) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		13 interacting genes: EGFR ERBB2 ERBB3 ERBB4 FLT1 GRB2 KDR KIT MET NTRK1 NTRK2 NTRK3 RPL36	28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13
Entrez ID		25759	4916
HPRD ID		19296	01870
Ensembl ID		ENSG00000129946	ENSG00000140538
Uniprot IDs		P98077	B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6
PDB IDs			1WWC 3V5Q 4YMJ 6KZC 6KZD
Enriched GO Terms of Interacting Partners?
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