EPGN and ADAM33

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EPGN	ADAM33
Description		epithelial mitogen	ADAM metallopeptidase domain 33
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Integral Component Of Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane	Integral Component Of Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation	Proteolysis
Pathways		PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS		Breast size ( 22747683) Immune reponse to smallpox (secreted IL-1beta) ( 22610502)	Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: ADAM33 CXCL9 MTIF3 TIMMDC1	33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21
Entrez ID		255324	80332
HPRD ID		10866	06173
Ensembl ID		ENSG00000182585	ENSG00000149451
Uniprot IDs		Q6UW88	A2A2L3 Q9BZ11
PDB IDs		5WB8	1R54 1R55
Enriched GO Terms of Interacting Partners?
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