ACKR1 and CXCL1

Number of citations of the paper that reports this interaction (PubMedID 7592830)
10

Data Source:
HPRD (in vivo, in vitro)

		ACKR1	CXCL1
Description		atypical chemokine receptor 1 (Duffy blood group)	C-X-C motif chemokine ligand 1
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GO Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Membrane Recycling Endosome	Extracellular Region Extracellular Space Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity C-C Chemokine Binding Signaling Receptor Activity	Signaling Receptor Binding Protein Binding Chemokine Activity Enzyme Activator Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Defense Response Inflammatory Response G Protein-coupled Receptor Signaling Pathway Regulation Of Chemokine Production Chemokine-mediated Signaling Pathway	Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Negative Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Neutrophil Chemotaxis Intracellular Signal Transduction Regulation Of Catalytic Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide
Pathways		Peptide ligand-binding receptors	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling Neutrophil degranulation
Drugs
Diseases
GWAS		Eotaxin levels ( 27989323) Growth-regulated protein alpha levels ( 27989323) Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Monocyte chemoattractant protein-1 levels ( 27989323 31217265) Neutrophil level response to clozapine in treatment-resistant schizophrenia ( 30647433)	Anxiety disorder ( 25390645) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Growth-regulated protein alpha levels ( 27989323) Inflammatory bowel disease ( 23128233)
Interacting Genes		10 interacting genes: CCL17 CCL2 CCL5 CCL7 CCL8 CD48 CXCL1 CXCL5 CXCL8 MTNR1B	13 interacting genes: ACKR1 CCL11 CXCL5 CXCL6 CXCR1 CXCR2 ESR1 HIPK2 HRAS MEOX2 MMP9 PTEN XRCC3
Entrez ID		2532	2919
HPRD ID		00192	01119
Ensembl ID		ENSG00000213088	ENSG00000163739
Uniprot IDs		Q16570 Q5Y7A1 Q5Y7A2	P09341
PDB IDs		4NUU 4NUV	1MGS 1MSG 1MSH 1ROD
Enriched GO Terms of Interacting Partners?
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