ALPL and ALOX5

Number of citations of the paper that reports this interaction (PubMedID 26210919)
2

Data Source:
BioGRID (enzymatic study)

		ALPL	ALOX5
Description		alkaline phosphatase, biomineralization associated	arachidonate 5-lipoxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrial Intermembrane Space Plasma Membrane Membrane Extracellular Matrix Anchored Component Of Membrane Mitochondrial Membrane Extracellular Exosome	Extracellular Region Extracellular Space Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytosol Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Ficolin-1-rich Granule Lumen
	Molecular Function	Alkaline Phosphatase Activity Protein Binding Pyrophosphatase Activity Metal Ion Binding Phosphoamidase Activity	Arachidonate 5-lipoxygenase Activity Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Arachidonate 8(S)-lipoxygenase Activity
	Biological Process	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Developmental Process Involved In Reproduction Dephosphorylation Response To Lipopolysaccharide Response To Vitamin D Response To Antibiotic Response To Glucocorticoid Cellular Response To Organic Cyclic Compound Cementum Mineralization	Negative Regulation Of Endothelial Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Humoral Immune Response Negative Regulation Of Angiogenesis Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Bone Mineralization Lipid Oxidation Dendritic Cell Migration Glucose Homeostasis Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Regulation Of Fat Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Insulin Secretion Hepoxilin Biosynthetic Process Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Regulation Of Inflammatory Response To Wounding Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Leukotriene A4 Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Lipoxin Biosynthetic Process
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives
Drugs		Mersalyl	Vitamin E Masoprocol Aminosalicylic acid Mesalazine Montelukast Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Morniflumate Diacerein Fostamatinib Rhein alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) B6 vitamer levels (multivariate analysis) ( 30583557) Blood metabolite ratios ( 24816252) Calcific aortic valve stenosis ( 32141789) Folate pathway vitamin levels ( 19303062 19744961) Heel bone mineral density ( 30598549) Hematological and biochemical traits ( 20139978) Kidney stones ( 26272126 31729369) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Phosphorus levels ( 29403010 20558539) Plasma pyridoxal phosphate to pyridoxal ratio ( 31641590) Pyridoxal 5'-phosphate levels ( 25972531 31641590) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 33547301 31666285 29403010 33339817) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urolithiasis ( 30975718) Vitamin B levels in ischemic stroke ( 25147783)	Alanine aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)
Interacting Genes		7 interacting genes: ALOX5 EEF1A1 MAP3K14 PCSK6 SRPK2 TRAF2 TRAF3	27 interacting genes: ACTB ALOX5AP ALPL APP C10orf67 CCDC174 CEP57L1 CEP63 COTL1 DICER1 GATC GRB2 HHIPL2 HSD17B1 LCN1 LTC4S MAD1L1 MAPKAPK2 MEOX1 MEOX2 MTDH NUTM1 OOEP REL SYCE1 TBC1D7 TGFBRAP1
Entrez ID		249	240
HPRD ID		01377	01065
Ensembl ID		ENSG00000162551	ENSG00000012779
Uniprot IDs		A0A024RAB4 P05186	P09917
PDB IDs			2ABV 3O8Y 3V92 3V98 3V99 6N2W 6NCF
Enriched GO Terms of Interacting Partners?
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