PELI3 and IRAK4

Number of citations of the paper that reports this interaction (PubMedID 17675297)
35

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PELI3	IRAK4
Description		pellino E3 ubiquitin protein ligase family member 3	interleukin 1 receptor associated kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Protein Polyubiquitination Toll Signaling Pathway Regulation Of Toll Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Toll-like Receptor Signaling Pathway Neutrophil Mediated Immunity MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation JNK Cascade Cytokine-mediated Signaling Pathway Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Interleukin-1-mediated Signaling Pathway Neutrophil Migration
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs			1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE Fostamatinib
Diseases
GWAS		Bipolar disorder ( 21926972)	Immune reponse to smallpox (secreted TNF-alpha) ( 22610502) Inflammatory bowel disease ( 27569725)
Interacting Genes		12 interacting genes: APP IRAK1 IRAK2 IRAK4 MAP3K14 MAP3K7 RIPK2 TRAF6 TRIM55 TRIM63 UBE2N UBE2V1	23 interacting genes: ARNT EIF4EBP1 ERBB3 H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 IKBKG IL36RN IRAK1 MBP MYD88 PELI1 PELI2 PELI3 TBPL1 TICAM2 TIRAP TRAF6 TRIM7 ZNF597
Entrez ID		246330	51135
HPRD ID		17535	06051
Ensembl ID		ENSG00000174516	ENSG00000198001
Uniprot IDs		A0A024R5B1 A0A024R5I2 Q8N2H9	B2RAP9 B4E359 Q69FE3 Q9NWZ3
PDB IDs			2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP 4RMZ 4U97 4U9A 4XS2 4Y73 4YO6 4YP8 4ZTL 4ZTM 4ZTN 5K72 5K75 5K76 5K7G 5K7I 5KX7 5KX8 5T1S 5T1T 5UIQ 5UIR 5UIS 5UIT 5UIU 5W84 5W85 6EG9 6EGA 6EGD 6EGE 6EGF 6F3D 6F3E 6F3G 6F3I 6LXY 6MOM 6N8G 6O8U 6O94 6O95 6O9D 6RFI 6RFJ 6THW 6THX 6THZ 6TI8 6TIA 6UYA 6VQL 7C2V 7C2W
Enriched GO Terms of Interacting Partners?
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