APOL2 and PANX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		APOL2	PANX1
Description		apolipoprotein L2	pannexin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Integral Component Of Membrane Bleb Protein-containing Complex
	Molecular Function	Signaling Receptor Binding Protein Binding High-density Lipoprotein Particle Binding Lipid Binding	Protease Binding Signaling Receptor Binding Structural Molecule Activity Calcium Channel Activity Protein Binding Wide Pore Channel Activity Leak Channel Activity Transmembrane Transporter Binding Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Acute-phase Response Multicellular Organism Development Cholesterol Metabolic Process Lipoprotein Metabolic Process Maternal Process Involved In Female Pregnancy	Response To Ischemia Cation Transport Calcium Ion Transport Cell-cell Signaling Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Response To ATP Oogenesis Calcium Ion Transmembrane Transport
Pathways			Electric Transmission Across Gap Junctions The NLRP3 inflammasome
Drugs			Probenecid
Diseases
GWAS		Epigenetic age acceleration in alcohol use disorder ( 31466081)	Alanine aminotransferase levels ( 33547301 34315874 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301 34315874 29403010 33339817) Autoimmune thyroid disease ( 32581359) Liver enzyme levels (alanine transaminase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		33 interacting genes: AIG1 APOC2 APOC4 AR BSND CISD2 CYBC1 EBAG9 EMP1 FAM209A GET1 GJB5 ITGB2 KCNA1 LMNA MARCHF3 MFF MGST3 PANX1 PSCA SFXN5 SIT1 SLC18A1 SLC26A6 STX1A STX2 TMED8 TMEM139 TMEM45B TMEM52B TMEM60 USE1 YIPF6	17 interacting genes: APOA2 APOL2 AQP2 BCL2L2 BUD31 CFHR5 CLCA4 FAXDC2 FDFT1 GNAS KEAP1 P2RX7 SLC38A7 TMEM229B TNF VAMP5 WFDC2
Entrez ID		23780	24145
HPRD ID		06263	10526
Ensembl ID		ENSG00000128335	ENSG00000110218
Uniprot IDs		A0A024R1M8 J3KQL8 Q9BQE5	A0A024R397 Q96RD7
PDB IDs			6LTN 6LTO 6M02 6M66 6M67 6M68 6V6D 6WBF 6WBG 6WBI 6WBK 6WBL 6WBM 6WBN
Enriched GO Terms of Interacting Partners?
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