KPNA6 and SMARCB1

Number of citations of the paper that reports this interaction (PubMedID 27229929)
8

Data Source:
BioGRID (two hybrid)

		KPNA6	SMARCB1
Description		karyopherin subunit alpha 6	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Host Cell	Nuclear Chromosome Chromatin Fibrillar Center XY Body Nucleus Nucleoplasm Nucleolus SWI/SNF Complex Protein-containing Complex Brahma Complex Intracellular Membrane-bounded Organelle NpBAF Complex NBAF Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	RNA Polymerase I Core Promoter Sequence-specific DNA Binding P53 Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Tat Protein Binding Nucleosomal DNA Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Maternal Process Involved In Female Pregnancy Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Viral Life Cycle	RNA Polymerase I Preinitiation Complex Assembly Blastocyst Hatching Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cell Cycle Nervous System Development Negative Regulation Of Cell Population Proliferation DNA Integration Cell Differentiation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation By Host Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K9 Dimethylation Negative Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Histone H4-K16 Acetylation
Pathways			RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Dilated cardiomyopathy ( 33677556) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional shortening ( 29403010) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) N-glycan levels ( 31163085)
Interacting Genes		38 interacting genes: ANKRD11 ANP32A ANP32B ARNT BRCA1 CDKN1B CREBBP CSE1L DCPS EPAS1 FAM90A1 FRG1BP GEMIN2 HIF1A IL1A JRK KAT5 KEAP1 KPNB1 LMNA LMNB1 MAGED1 NMNAT1 NOP2 NUP50 OGT POLR3C POM121 POU6F2 RAC1 RELB RNMT SKP2 SMARCB1 STAT1 STAT3 TAF9 ZNF131	114 interacting genes: ABI2 AKT1 APP ARL11 ATP5F1A BCL2L11 BHLHE40 BLZF1 CALR CAMK2D CCDC120 CCDC33 CD69 CDC23 CDX2 CEBPB CHFR CNTNAP3 CXCL11 CYB5D2 DNAJA3 DPH6 FAM90A1 FAM9B FUS GADD45G GATA1 GFAP GOLGA2 HGS HNRNPM HOMEZ HOOK2 HSF2BP HSFY1 IHO1 IKZF3 IL16 KCTD9 KLC3 KLF1 KMT2B KMT2C KPNA6 KRT15 KRT19 KRT6A KRT6B KRT6C LDOC1 LENG8 LNX2 LY96 LZTS2 MAP1LC3B MAP3K20 MAPK8IP2 MBIP MCPH1 MECP2 MESD MIF4GD MRPL53 MXI1 MYC MYO18B NCK2 NONO NR0B2 NR3C1 OSGIN1 OTX2 PDPK1 PICK1 PPP1CC PPP1R15A PRKAB2 PRMT5 PSMB1 RAN RB1 RELB RINT1 RPN1 RPS6KA5 RUSC1 RXRA SAXO1 SIN3B SMARCA4 SMARCD1 SRC TACC2 TAF1D TASOR2 TEKT5 TFIP11 TLE5 TNFAIP1 TNRC6A TP53 TRIM14 TRIM27 TRIM35 TSC22D4 UBQLN4 VIM VPREB3 XPO1 YEATS4 ZC3H11A ZDHHC17 ZNF398 ZNF688
Entrez ID		23633	6598
HPRD ID		09465	03364
Ensembl ID		ENSG00000025800	ENSG00000099956
Uniprot IDs		O60684	G5E975 Q12824 Q9H836
PDB IDs		4UAD	5AJ1 5GJK 5L7A 5L7B 6AX5 6KAG 6KZ7 6LTH 6LTJ 6UCH
Enriched GO Terms of Interacting Partners?
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