CD2AP and NPHS1

Number of citations of the paper that reports this interaction (PubMedID 10997929)
38

Data Source:
HPRD (in vivo)

		CD2AP	NPHS1
Description		CD2 associated protein	NPHS1 adhesion molecule, nephrin
Image
GO Annotations	Cellular Component	Fibrillar Center Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Filamentous Actin Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Slit Diaphragm Cell Projection Extracellular Exosome
	Molecular Function	Vascular Endothelial Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Beta-catenin Binding Protein C-terminus Binding SH3 Domain Binding Identical Protein Binding Protein-containing Complex Binding Cadherin Binding	Protein Binding Myosin Binding Cell Adhesion Molecule Binding
	Biological Process	Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Cell Cycle Signal Transduction Vesicle Organization Negative Regulation Of Transforming Growth Factor Beta1 Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Protein Secretion Negative Regulation Of Small GTPase Mediated Signal Transduction Cell Division Protein-containing Complex Assembly Cell-cell Adhesion Positive Regulation Of Protein Localization To Nucleus Regulation Of Actin Cytoskeleton Reorganization	Cell Adhesion JNK Cascade Skeletal Muscle Tissue Development Myoblast Fusion Excretion Positive Regulation Of Actin Filament Polymerization Glomerular Basement Membrane Development Protein Localization To Synapse Regulation Of Excretion Glomerular Visceral Epithelial Cell Development Cell-cell Adhesion
Pathways		Nephrin family interactions	Nephrin family interactions Nephrin family interactions
Drugs
Diseases
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Plasma homocysteine levels ( 26519441) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		34 interacting genes: ARAP3 BCAR1 CAPZA1 CBL CBLB CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A RIN3 SH3GL2 SOS1 SOS2 SRC UBC UBE2I WTIP YES1	11 interacting genes: CASK CD2AP FYN IQGAP1 KIRREL1 LYN NCK1 NCK2 NPHS2 SRC YES1
Entrez ID		23607	4868
HPRD ID		05026	04094
Ensembl ID		ENSG00000198087	ENSG00000161270
Uniprot IDs		Q9Y5K6	O60500
PDB IDs		2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23 4WCI 4X1V 7DS6 7DS8	4ZRT
Enriched GO Terms of Interacting Partners?
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