NNT and MVP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		NNT	MVP
Description		nicotinamide nucleotide transhydrogenase	major vault protein
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respirasome Membrane Integral Component Of Membrane	Extracellular Region Nucleus Nuclear Pore Cytoplasm Cytosol Cytoskeleton Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	NAD(P)+ Transhydrogenase (B-specific) Activity NAD(P)+ Transhydrogenase Activity NADP Binding NAD Binding	Protein Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Tricarboxylic Acid Cycle NADPH Regeneration Positive Regulation Of Mitochondrial Membrane Potential Oxygen Homeostasis Response To Vitamin Negative Regulation Of Apoptotic Process Cell Redox Homeostasis Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Proton Transmembrane Transport Positive Regulation Of Hydrogen Peroxide Catabolic Process	Protein Transport Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity
Pathways		Citric acid cycle (TCA cycle)	Neutrophil degranulation
Drugs		NADH 7-thionicotinamide-adenine-dinucleotide phosphate Nicotinamide adenine dinucleotide phosphate Xanthinol
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 30224653) Subcutaneous adipose tissue ( 29178545)	Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		1 interacting genes: MVP	68 interacting genes: ADAMTSL4 BANP C1orf94 CALCOCO2 CAMK2B CKAP4 DISC1 DLX2 DNAH5 DTX2 EPHX2 ESR1 FMR1 FNDC3B FXR1 FXR2 GIT2 GOLGA2 HP IHO1 KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MRTFA MT-CYB NNT NOTCH2NLA NRF1 NTAQ1 PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF111 SAXO1 SERTAD1 SKIL SLC2A4 STN1 TCF4 TENT5C TFCP2 TLE5 TOLLIP TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 TSPOAP1 UBC UBTD2 VAC14 ZBTB32 ZMIZ2
Entrez ID		23530	9961
HPRD ID		09715	05475
Ensembl ID		ENSG00000112992	ENSG00000013364
Uniprot IDs		A0A024R0C3 E9PCX7 Q13423	Q14764 X5D2M8 X5D7K9 X5DNU0
PDB IDs		1DJL 1PT9 1U31	1Y7X
Enriched GO Terms of Interacting Partners?
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