ICMT and KCNJ6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ICMT	KCNJ6
Description		isoprenylcysteine carboxyl methyltransferase	potassium inwardly rectifying channel subfamily J member 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Protein C-terminal Carboxyl O-methyltransferase Activity Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity Protein Binding	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity
	Biological Process	Cellular Protein Modification Process C-terminal Protein Methylation Protein Targeting To Membrane	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Gamma carboxylation, hypusine formation and arylsulfatase activation RAS processing	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Ethanol Halothane Ifenprodil Isavuconazole
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624 28270201)	Body size at age 10 ( 32376654) Clostridioides difficle infection ( 33841421) Electroencephalographic traits in alcoholism ( 22554406) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Rosacea symptom severity ( 29771307)
Interacting Genes		12 interacting genes: AQP6 ARL13B HRAS JAGN1 KCNJ6 MUC1 PDZK1IP1 RAC1 RAC2 RHOA RNF19B TRIM32	64 interacting genes: ADRB2 AIG1 APOD BCL2L2 BET1 BIRC5 C14orf180 CMTM5 CNPY3 COL4A5 DLG1 DRD2 EDDM3B ERG28 FAM20B FIS1 FUNDC2 FXYD6 GABBR1 HMOX2 ICMT ITGAM KCNJ3 KCNJ9 LEPROTL1 LPAR3 LPCAT2 MIP MYO15B NINJ2 ORMDL2 PEX11G PEX16 PLLP PMP22 PNLIPRP1 RPRM RPS6KA2 RTP2 SCAMP4 SCARF1 SCD SERTM1 STATH STRIT1 SYT3 THSD7B TM6SF2 TMEM107 TMEM120B TMEM203 TMEM208 TMEM218 TMPPE TNFRSF10C TSPO2 UBIAD1 UNC50 UPK1B VSTM1 XIAP YIPF1 YIPF6 ZDHHC24
Entrez ID		23463	3763
HPRD ID		09321	02929
Ensembl ID		ENSG00000116237	ENSG00000157542
Uniprot IDs		A0A024R4F6 B3KS61 O60725	P48051
PDB IDs
Enriched GO Terms of Interacting Partners?
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