OTP and EOMES

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		OTP	EOMES
Description		orthopedia homeobox	eomesodermin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleoplasm Nuclear Body	Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuroblast Proliferation Forebrain Neuron Differentiation Hypothalamus Cell Differentiation Neurohypophysis Development Neuron Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Endoderm Formation Mesoderm Formation Cell Fate Specification Endodermal Cell Fate Specification Adaptive Immune Response CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Regulation Of Transcription By RNA Polymerase II Brain Development Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Involved In Embryonic Placenta Development Mesodermal To Mesenchymal Transition Involved In Gastrulation
Pathways
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149)	Ankylosing spondylitis ( 23749187) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 28165464 26956414) Diastolic blood pressure ( 27841878) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Hodgkin's lymphoma ( 24149102) Lymphocyte counts ( 32888494) Macular telangiectasia type 2 ( 33654266) Macular thickness ( 30535121) Mean arterial pressure ( 29403010) Multiple sclerosis ( 31604244 22190364 24076602 21833088) PR interval ( 30046033) Pulse pressure ( 29403010) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966) Systolic blood pressure ( 29403010) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: BEX1 CCL21 CDK6 CPNE7 EOMES PDE6D SLC12A7 TPGS2	2 interacting genes: OTP PFDN1
Entrez ID		23440	8320
HPRD ID		05166	07054
Ensembl ID		ENSG00000171540	ENSG00000163508
Uniprot IDs		Q5XKR4	B7Z4K0 O95936
PDB IDs
Enriched GO Terms of Interacting Partners?
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