HARS2 and MIR17

Number of citations of the paper that reports this interaction (PubMedID 28431233)
92

Data Source:
BioGRID (unspecified method)

		HARS2	MIR17
Description		histidyl-tRNA synthetase 2, mitochondrial	microRNA 17
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Extracellular Space Mitochondrion Extracellular Exosome Extracellular Vesicle
	Molecular Function	RNA Binding Histidine-tRNA Ligase Activity Protein Binding ATP Binding Identical Protein Binding	MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation	Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Morphogenesis Negative Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Transporter Activity Negative Regulation Of Toll-like Receptor Signaling Pathway Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Pressure Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Phagocytosis Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Apoptosome Assembly Positive Regulation Of Pulmonary Blood Vessel Remodeling Positive Regulation Of Smooth Muscle Hypertrophy Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Negative Regulation Of Cellular Senescence Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)
Interacting Genes		22 interacting genes: AGTRAP BST2 MIR106B MIR128-2 MIR141 MIR145 MIR16-2 MIR17 MIR18B MIR199A1 MIR19B1 MIR19B2 MIR29A MIR29B1 MIR34A MIR34B MIR9-1 MIR92A2 MIR93 MIRLET7F1 MIRLET7I OGT	84 interacting genes: AIMP1 APOBEC3B ATXN2L C1QBP CELF1 CPSF6 CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUM1 PUM2 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRMT1L UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZNF346
Entrez ID		23438	406952
HPRD ID		02871
Ensembl ID		ENSG00000112855	ENSG00000284536
Uniprot IDs		A0A2R8Y6I1 B4DDN8 P49590
PDB IDs
Enriched GO Terms of Interacting Partners?
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