SLC7A8 and SIGLEC5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SLC7A8	SIGLEC5
Description		solute carrier family 7 member 8	sialic acid binding Ig like lectin 5
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Microvillus Membrane	Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity Glycine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Peptide Antigen Binding	Protein Binding Carbohydrate Binding Sialic Acid Binding
	Biological Process	Amino Acid Transmembrane Transport Amino Acid Transport Response To Toxic Substance Organic Cation Transport Neutral Amino Acid Transport Glycine Transport Leucine Transport Tryptophan Transport Valine Transport Proline Transmembrane Transport Metal Ion Homeostasis Thyroid Hormone Transport Amino Acid Import Across Plasma Membrane Leucine Import Across Plasma Membrane Transport Across Blood-brain Barrier Toxin Transport L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane	Cell Adhesion
Pathways		Basigin interactions Amino acid transport across the plasma membrane	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs		Phenylalanine Alanine
Diseases
GWAS			Addison's disease ( 33574239) Aggressive periodontitis ( 28449029) Blood protein levels ( 29875488 28240269) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Leprosy ( 25642632) Lymphocyte counts ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Periodontitis ( 30218097) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 33272962)
Interacting Genes		26 interacting genes: ABHD16A AGPAT4 AQP6 COMT DERL1 FXYD6-FXYD2 MFF MFSD3 NDUFA3 NINJ2 REEP4 SIGLEC5 SLC25A46 SLC30A2 SLC3A1 SLC3A2 SMPD2 SNORC SYCE1L SYNJ2BP TMEM14B TMEM208 TMEM60 TMEM65 YIPF1 YIPF6	5 interacting genes: LGALS3BP NAPB SLC7A8 TRIP13 VAC14
Entrez ID		23428	8778
HPRD ID		11971	05011
Ensembl ID		ENSG00000092068	ENSG00000268500
Uniprot IDs		Q53EM9 Q9UHI5	O15389
PDB IDs		7CMH 7CMI	2ZG1 2ZG2 2ZG3
Enriched GO Terms of Interacting Partners?
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