MAN2B2 and KCNK5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MAN2B2	KCNK5
Description		mannosidase alpha class 2B member 2	potassium two pore domain channel subfamily K member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Vacuolar Membrane Lysosomal Lumen Extracellular Exosome	Integral Component Of Plasma Membrane
	Molecular Function	Alpha-mannosidase Activity Protein Binding Carbohydrate Binding Metal Ion Binding	Voltage-gated Ion Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Leak Channel Activity
	Biological Process	Mannose Metabolic Process	Potassium Ion Transport Excretion Stabilization Of Membrane Potential Regulation Of Ion Transmembrane Transport Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane
Pathways		Lysosomal oligosaccharide catabolism	Phase 4 - resting membrane potential
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483)	Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Eating disorders ( 23568457) Fasting plasma glucose ( 32682390) HDL cholesterol levels ( 32203549) Hypertension in type 2 diabetes ( 33276381) Kidney stones ( 31729369) Migraine ( 27322543) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Social communication problems ( 24564958) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urolithiasis ( 30975718)
Interacting Genes		9 interacting genes: APPBP2 CISD2 CPLX4 CREB3L1 FKBP7 GPX8 KCNK5 KRTAP3-2 LIME1	30 interacting genes: ADIPOQ AGTRAP APP AQP1 ATP5PF BNIP2 CMTM5 COMT CYB5B FRAT1 GJB2 IGFBP5 LHFPL5 MAN2B2 ORMDL3 SLC66A2 SMCO4 STRIT1 TM4SF4 TMEM128 TMEM14A TMEM176A TMEM218 TMEM54 TMEM60 TNFRSF10C TSPAN33 VAMP3 YIF1A YIPF6
Entrez ID		23324	8645
HPRD ID		14355	04604
Ensembl ID		ENSG00000013288	ENSG00000164626
Uniprot IDs		B7Z754 E9PCD7 Q9Y2E5	A0A024RD32 A0A0B6VPR3 O95279
PDB IDs
Enriched GO Terms of Interacting Partners?
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