SATB2 and PIAS1

Number of citations of the paper that reports this interaction (PubMedID 14701874)
97

Data Source:
HPRD (in vitro, in vivo)

		SATB2	PIAS1
Description		SATB homeobox 2	protein inhibitor of activated STAT 1
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GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleoplasm Transcription Regulator Complex Nuclear Matrix	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Histone Deacetylase Binding	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding SUMO Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Osteoblast Development Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Embryonic Pattern Specification Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Cartilage Development Roof Of Mouth Development Cellular Response To Organic Substance	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Visual Learning Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Differentiation Protein-DNA Complex Assembly
Pathways		SUMOylation of chromatin organization proteins RUNX2 regulates osteoblast differentiation	SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Brain cytoarchitecture ( 20308991) Cerebrospinal fluid immune biomarker levels ( 32066700) Chin dimples ( 27182965) Colorectal cancer or advanced adenoma ( 30510241) Cortical volume ( 32963231) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Height ( 31562340) Insomnia ( 23728906) Loneliness (multivariate analysis) ( 27629369) Lung function (FVC) ( 30804560) Menarche (age at onset) ( 27182965 29773799 25231870) Rheumatoid arthritis ( 30891314) Schizophrenia ( 28991256 25056061 29483656 30285260) Serum alkaline phosphatase levels ( 33547301) Sun-seeking behavior ( 32920024) Type 2 diabetes ( 25760438) Ulcerative colitis ( 20228799) Waist circumference ( 23966867)	Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Haemorrhoidal disease ( 33888516) Major depressive disorder ( 23377640) Number of twin births ( 30760885)
Interacting Genes		7 interacting genes: ABI2 ADAM23 HDAC1 MTA2 PIAS1 POLR2J3 RAB3IL1	110 interacting genes: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CASP8 CBS CDK4 CEBPA CEBPE CHD3 CHUK CNOT7 CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 EP300 ESR1 ESR2 FANCI FHL3 FLI1 GATA4 GLUL GRM8 GSK3B GTF2IRD1 HECTD2 HIC1 HTT IKZF5 JUN KLF3 L3MBTL2 LSM3 MAML1 MBD1 MDC1 MDM2 MITF MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRPF40A PSME3 PTK2 PTPN1 QKI RAD54L2 RBBP6 RELA RPA2 SATB1 SATB2 SERBP1 SGTA SKIL SMAD1 SMAD4 SMAD7 SNAI2 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO1P1 SUMO2 SUMO3 TBP TERF2 TEX11 TP53 TP73 TRIM27 TRIM5 TRIM55 TRIM63 TSG101 UBE2I UBE2L3 YWHAZ ZBED1 ZNF451 ZNF76
Entrez ID		23314	8554
HPRD ID		12178	16029
Ensembl ID		ENSG00000119042	ENSG00000033800
Uniprot IDs		A0A024R3U6 B3KPQ9 Q59FT3 Q9UPW6	O75925 Q1XBU8
PDB IDs		1WI3 1WIZ 2CSF	1V66
Enriched GO Terms of Interacting Partners?
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