AGTPBP1 and TNIK

Number of citations of the paper that reports this interaction (PubMedID 17043677)
193

Data Source:
BioGRID (two hybrid)

		AGTPBP1	TNIK
Description		ATP/GTP binding carboxypeptidase 1	TRAF2 and NCK interacting kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Intracellular Membrane-bounded Organelle Axon Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Metallocarboxypeptidase Activity Zinc Ion Binding Tubulin Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Eye Photoreceptor Cell Differentiation Proteolysis Mitochondrion Organization Adult Walking Behavior Negative Regulation Of Cell Population Proliferation Cerebellar Purkinje Cell Differentiation Olfactory Bulb Development Central Nervous System Neuron Development Protein Deglutamylation C-terminal Protein Deglutamylation Protein Side Chain Deglutamylation Neurotransmitter Metabolic Process Neuromuscular Process Retina Development In Camera-type Eye Anterograde Axonal Transport Of Mitochondrion Retrograde Axonal Transport Of Mitochondrion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Reorganization Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways		Carboxyterminal post-translational modifications of tubulin	Oxidative Stress Induced Senescence
Drugs			Fostamatinib
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258)	Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458)
Interacting Genes		10 interacting genes: CBY1 CYCS DISC1 ENO1 NYNRIN PPFIA1 PPFIA4 PYGM TNIK UBC	37 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Entrez ID		23287	23043
HPRD ID		08442	18206
Ensembl ID		ENSG00000135049	ENSG00000154310
Uniprot IDs		A0A024R288 J3KNS1 Q9UPW5	Q9UKE5
PDB IDs			2X7F 5AX9 5CWZ 5D7A 6RA5 6RA7
Enriched GO Terms of Interacting Partners?
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