POFUT2 and CLDN14

		POFUT2	CLDN14
Description		protein O-fucosyltransferase 2	claudin 14
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi Apparatus	Endoplasmic Reticulum Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane
	Molecular Function	Peptide-O-fucosyltransferase Activity	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Mesoderm Formation Fucose Metabolic Process Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Protein O-linked Fucosylation Regulation Of Secretion Positive Regulation Of Protein Folding	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Protein-containing Complex Assembly Bicellular Tight Junction Assembly
Pathways		O-glycosylation of TSR domain-containing proteins	Tight junction interactions
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Suicide attempt severity in mood disorders ( 33783297)	Blood urea nitrogen levels ( 31152163) Bone mineral density ( 24249740) Estimated glomerular filtration rate ( 31152163 31015462) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Kidney stones ( 26272126 19561606 31729369) Obsessive-compulsive traits ( 33531474) Red blood cell count ( 32888494) Serum parathyroid hormone levels ( 27927781) Urate levels ( 31578528) Urinary electrolytes (magnesium/calcium ratio) ( 27915449) Urolithiasis ( 30975718)
Interacting Genes		2 interacting genes: BACE2 CLDN14	7 interacting genes: C2CD2 CTXN3 MAL PLEKHA1 PLLP POFUT2 RRP1B
Entrez ID		23275	23562
HPRD ID		09846	05727
Ensembl ID		ENSG00000186866	ENSG00000159261
Uniprot IDs		Q9Y2G5 S6FW71	O95500
PDB IDs		4AP5 4AP6
Enriched GO Terms of Interacting Partners?
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