MCF2L and RHOG

Number of citations of the paper that reports this interaction (PubMedID 12376551)
57

Data Source:
HPRD (in vitro)

		MCF2L	RHOG
Description		MCF.2 cell line derived transforming sequence like	ras homolog family member G
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane Endomembrane System	Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Secretory Granule Membrane Cytoplasmic Vesicle Cell Projection Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Phosphatidylinositol Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Rac Protein Signal Transduction Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Engulfment Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Cell Chemotaxis Activation Of GTPase Activity Regulation Of Ruffle Assembly Regulation Of Neutrophil Migration Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle	GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Cutaneous malignant melanoma ( 32341527) Diastolic blood pressure ( 27841878) Factor VII ( 17903294) Mean platelet volume ( 32888494) Osteoarthritis ( 21871595) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 28135244 27841878 30578418)	Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Plateletcrit ( 32888494)
Interacting Genes		7 interacting genes: AIMP2 CDC42 RABAC1 RAC1 RHOA RHOG YAE1	21 interacting genes: ARHGDIA ARHGDIG CCR2 DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 ERCC6 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3
Entrez ID		23263	391
HPRD ID		14371	01537
Ensembl ID		ENSG00000126217	ENSG00000177105
Uniprot IDs		O15068	P84095 Q6ICQ8
PDB IDs			6UKA
Enriched GO Terms of Interacting Partners?
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