COBL and NLGN3

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		COBL	NLGN3
Description		cordon-bleu WH2 repeat protein	neuroligin 3
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Actin Filament Plasma Membrane Cell Cortex Membrane Axon Dendrite Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Terminal Web	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Synapse Excitatory Synapse Spanning Component Of Membrane Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Asymmetric, Glutamatergic, Excitatory Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Actin Monomer Binding Protein Binding	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Embryonic Axis Specification Somite Specification Neural Tube Closure Liver Development Actin Filament Polymerization Notochord Development Floor Plate Development Digestive Tract Development Collateral Sprouting In Absence Of Injury Actin Filament Network Formation Positive Regulation Of Dendrite Development Positive Regulation Of Ruffle Assembly	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Receptor-mediated Endocytosis Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Inhibitory Postsynaptic Potential Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Alzheimer's disease ( 33074286) Autoimmune traits (pleiotropy) ( 30572963) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Fractures ( 30158200) Late-onset Alzheimer's disease ( 27770636) Macular thickness ( 30535121) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730) Type 1 diabetes ( 19430480) Urate levels in obese individuals ( 25811787) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920) Wegener's granulomatosis ( 23740775)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Prostate cancer ( 25217961)
Interacting Genes		3 interacting genes: ALAS1 NLGN3 PACSIN2	66 interacting genes: AKT1 ALPP AP2A2 APC2 ATF4 ATXN1 C1orf122 C1QA CCAR2 CGB3 COBL CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFEMP1 EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 HIVEP1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12 PDZD11 PICK1 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 RBFOX2 SPAG5 SPINT1 SSR4 TDRD7 TLE5 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1
Entrez ID		23242	54413
HPRD ID		10843	02275
Ensembl ID		ENSG00000106078	ENSG00000196338
Uniprot IDs		O75128	B7Z3P8 Q4G160 Q6MZK0 Q9NZ94 X5D2P6 X5D7L6 X5DNV3
PDB IDs		4PL8
Enriched GO Terms of Interacting Partners?
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