FLT4 and PNPLA8

		FLT4	PNPLA8
Description		fms related receptor tyrosine kinase 4	patatin like phospholipase domain containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Mitochondrion Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Phosphatase Binding Protein Homodimerization Activity	Phospholipase Activity Lysophospholipase Activity ATP Binding Calcium-independent Phospholipase A2 Activity Phosphatidyl Phospholipase B Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Hematopoietic Progenitor Cell Differentiation Respiratory System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Blood Vessel Morphogenesis Regulation Of Blood Vessel Remodeling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Kinase C Signaling	Prostaglandin Biosynthetic Process Fatty Acid Metabolic Process Cell Death Arachidonic Acid Metabolic Process Cardiolipin Metabolic Process Phosphatidylcholine Catabolic Process Linoleic Acid Metabolic Process Phosphatidylethanolamine Catabolic Process Arachidonic Acid Secretion Lipid Homeostasis Triglyceride Homeostasis Regulation Of Cellular Response To Oxidative Stress
Pathways		VEGF binds to VEGFR leading to receptor dimerization NOTCH4 Intracellular Domain Regulates Transcription	Acyl chain remodelling of PC Acyl chain remodelling of PE
Drugs		Sorafenib Sunitinib Vatalanib TG-100801 Denibulin ABT-869 IMC-1C11 Pazopanib Axitinib Regorafenib Lenvatinib Nintedanib Fostamatinib Selpercatinib
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Platelet distribution width ( 32888494) Serum folate levels ( 29953918)	JT interval (sulfonylurea treatment interaction) ( 27958378) Post bronchodilator FEV1/FVC ratio ( 26634245) Smoking behavior ( 22006218) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		20 interacting genes: ATF7IP DUSP19 ERBB2 GRB2 GRIA1 HNRNPH1 IKBKG ITGA5 ITGB1 KDR LRRK1 NEDD4 NKX2-5 PNPLA8 PTK2 PTPN11 SHC1 SHC3 VEGFC VEGFD	1 interacting genes: FLT4
Entrez ID		2324	50640
HPRD ID		00636	13741
Ensembl ID		ENSG00000037280	ENSG00000135241
Uniprot IDs		P35916	A0A024R746 Q9NP80
PDB IDs		4BSJ 4BSK
Enriched GO Terms of Interacting Partners?
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