ARC and TBX18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ARC	TBX18
Description		activity regulated cytoskeleton associated protein	T-box transcription factor 18
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytosol Plasma Membrane Cell Cortex Actin Cytoskeleton Early Endosome Membrane Neuronal Cell Body Dendritic Spine Membrane Raft Neuronal Ribonucleoprotein Granule Postsynaptic Density Membrane Postsynaptic Endosome Glutamatergic Synapse Extracellular Vesicle	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Repressor Complex
	Molecular Function	MRNA Binding Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Endocytosis Cytoskeleton Organization Endoderm Development Learning Long-term Memory Anterior/posterior Pattern Specification Cell Migration Regulation Of Cell Morphogenesis Regulation Of Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission MRNA Transport Protein Homooligomerization Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Regulation Of Dendritic Spine Morphogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Intercellular Transport Regulation Of Long-term Synaptic Potentiation Regulation Of Long-term Synaptic Depression Positive Regulation Of AMPA Receptor Activity	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Somitogenesis Sinoatrial Node Development Regulation Of Transcription By RNA Polymerase II Morphogenesis Of Embryonic Epithelium Smooth Muscle Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Sinoatrial Node Cell Fate Commitment Sinoatrial Node Cell Development Ureter Development Cochlea Morphogenesis Regulation Of SA Node Cell Action Potential
Pathways		NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Automobile speeding propensity ( 30643258)	Diabetic retinopathy in type 2 diabetes ( 25364816) Lung function ( 31902109) Monobrow ( 27182965) Pulse pressure ( 30224653) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		7 interacting genes: CSRP2 KRT15 S100P SH2D4A SPTBN4 TBX18 UBE3A	4 interacting genes: ARC KRTAP8-1 PLEKHG4 TRAF1
Entrez ID		23237	9096
HPRD ID		12469	19076
Ensembl ID		ENSG00000198576	ENSG00000112837
Uniprot IDs		Q7LC44	O95935
PDB IDs		6TN7 6TNQ 6TQ0 6YTU
Enriched GO Terms of Interacting Partners?
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