RCOR1 and FOXK2

Number of citations of the paper that reports this interaction (PubMedID 27773593)
25

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, biochemical, pull down)

		RCOR1	FOXK2
Description		REST corepressor 1	forkhead box K2
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex DNA Repair Complex	Chromatin Nucleus Nucleoplasm Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Enzyme Binding	Magnesium Ion Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Histone Deacetylation Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Histone H4 Deacetylation	Negative Regulation Of Transcription By RNA Polymerase II Cellular Glucose Homeostasis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy Regulation Of Glucose Metabolic Process Response To Starvation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Canonical Glycolysis
Pathways		HDACs deacetylate histones Regulation of PTEN gene transcription Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production	UCH proteinases
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Body mass index ( 26426971) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Homeostasis model assessment of insulin resistance ( 33381925) Immature fraction of reticulocytes ( 32888494 27863252) LDL cholesterol levels in HIV infection ( 33109212) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Platelet count ( 22139419 32888494 27863252) Plateletcrit ( 32888494 27863252) Tinnitus ( 33742053)	Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lean body mass ( 28552196) Letter-number span reordering ( 31596458) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		12 interacting genes: CTBP1 FOXK2 H3-4 HDAC2 KDM1A PHF21A REST SMARCE1 SNAI1 SUB1 SUMO2 ZMYM2	11 interacting genes: ASXL1 ESR1 HCFC1 IL2 MTA3 RBBP4 RBBP7 RCOR1 SIN3A TBL1X TBL1XR1
Entrez ID		23186	3607
HPRD ID		09645	00982
Ensembl ID		ENSG00000089902	ENSG00000141568
Uniprot IDs		Q9UKL0	Q01167
PDB IDs		2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1 4BAY 4KUM 4UV8 4UV9 4UVA 4UVB 4UVC 4UXN 4XBF 5H6Q 5H6R 5L3B 5L3C 5L3D 5L3E 5L3F 5L3G 5LBQ 5LGN 5LGT 5LGU 5LHG 5LHH 5LHI 5X60 5YJB 6K3E 6KGK 6KGL 6KGM 6KGN 6S35 6TE1 6VYP 6W4K	1JXS 2C6Y
Enriched GO Terms of Interacting Partners?
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