FLG and PCSK6

Number of citations of the paper that reports this interaction (PubMedID 11380615)
18

Data Source:
HPRD (in vitro)

		FLG	PCSK6
Description		filaggrin	proprotein convertase subtilisin/kexin type 6
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytosol Intermediate Filament Keratohyalin Granule Cytoplasmic Ribonucleoprotein Granule Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Skin Epidermis Transition Metal Ion Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Nerve Growth Factor Binding
	Biological Process	Multicellular Organism Development Peptide Cross-linking Keratinocyte Differentiation Establishment Of Skin Barrier	Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Production Secretion By Cell Regulation Of Lipoprotein Lipase Activity
Pathways		Formation of the cornified envelope	Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23886662 21666691 25574825 26482879) Atopic march ( 26542096) Eating disorders ( 23568457) Eczema ( 31361310) Male-pattern baldness ( 28196072)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Severe coronary stenosis (young age of onset interaction) ( 33766035) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)
Interacting Genes		3 interacting genes: CSNK2A1 PCSK6 UCHL5	12 interacting genes: ALPL CACNA1A FLG FN3K IGF1R IL16 PCSK5 PMCH RCN3 SNRPA1 SYNM ZNF441
Entrez ID		2312	5046
HPRD ID		15920	01329
Ensembl ID		ENSG00000143631	ENSG00000140479
Uniprot IDs		P20930	A2RQD9 H7BXT3 P29122 Q59H04
PDB IDs		4PCW
Enriched GO Terms of Interacting Partners?
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